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You may be eligible to participate in a plasmodium falciparum malaria drug resistant clinical trial. Have you or your loved ones been diagnosed with plasmodium falciparum malaria drug resistant? What is a clinical trial? Is participating in a clinical trial right for you? Learn more. The purpose of this study is to provide a new drug combination for a better treatment of P. The slow and incomplete clearance of parasites following ACT treatment is considered to permit the selection of resistant parasites.

The availability of new, more efficient treatments accelerating the clearance of parasites is therefore needed to counteract the selection of ART resistant strains. This positive effect is further potentiated by low concentrations of PPQ.

IMA is active both on the intra-erythrocyte asexual forms and on gametocytes. It is therefore expected that the combination DHA-PPQ-IMA should lead to faster and radical clearance of the parasites, therefore reducing the frequency of healthy carriers and transmission. Outcome measures are the tests that investigators perform to prove whether or not a treatment being tested in a clinical trial is having any effect.

Mean parasite clearance half-life calculated using parasitemia measured at baseline, 12 and 24 hours post-treatment. Percentage of patients with fever or malaria symptoms observed at Phisical Visit at day 3 and Parasitemia is determined by assessing the parasite count in blood, using thin film, thick film and qPCR analysis.