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Critical to advancing our understanding of neonatal AKI is collaborative research among neonatologists and nephrologists. A Steering Committee and four subcommittees were created. Inclusion and exclusion criteria were applied to eliminate neonates with a low likelihood of AKI. NKC investigators will disseminate data through peer-reviewed publications and educational conferences.

In addition to validating the neonatal AKI definition and identifying risk factors for AKI, this study will uncover variations in practice patterns related to fluid provision, renal function monitoring, and involvement of pediatric nephrologists during hospitalization.

Over the last decade, the nephrology and critical care communities have repeatedly shown that acute kidney injury AKI in children 1 , 2 and adults 3 — 7 portends poor short-term and long-term outcomes independent of severity of illness. The available short-term outcome data in neonates are similar: neonates with AKI have increased rates of mortality and longer hospital stays as compared to those without AKI Table 1 8 — However, prevalence estimates and data on short-term outcomes are solely derived from small retrospective, single-center studies.

Moreover, little is known about the long-term consequences of neonatal AKI Many significant questions, including how to best define, risk factors for, incidence of, association with other co-morbidities, and the short-term and long-term outcomes after AKI remain unanswered. Critical to advancing the field of neonatal AKI is collaborative research among neonatologists and pediatric nephrologists.