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Share sensitive information only on official, secure websites. Christine M. Fill, MD 1 ; Kara J. Levinson, PhD 10 ; Tim F. Newhouse, MD 1 ; John R. Syndromic polymerase chain reaction panels test for pathogens that can cause rash illnesses, including measles.
Rash illnesses have many causes. Their results were attributed to detection of measles vaccine virus. After vaccination, syndromic panels can detect measles vaccine virus, which is not transmitted to others and does not cause disease in immunocompetent persons. Any detection of measles virus should be immediately reported to public health agencies to determine appropriate public health response.
Syndromic polymerase chain reaction PCR panels are used to test for pathogens that can cause rash illnesses, including measles. No evidence exists of person-to-person transmission of measles vaccine virus, and illness does not typically result among immunocompetent persons. Both reports involved children aged 1 and 6 years without known risk factors for measles, who were evaluated for rash that occurred 11—13 days after routine MMR vaccination.
After public health responses in Tennessee determined that both PCR panels had detected measles vaccine virus, six state health departments collaborated to assess the frequency and characteristics of persons receiving a positive measles PCR panel test result in the United States.