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Objectives: Severe pneumonia is one of the most infections among critically ill patients, associated with a high mortality rate. Sitafloxacin is a new fluoroquinolone antimicrobial agent with broad-spectrum activity, including multidrug-resistant organisms. Additionally, sitafloxacin showed a potent in vitro activity against nosocomial respiratory tract pathogens e. Sitafloxacin has been approved for oral formulation and used in Thailand for treatment of urinary tract infections and lower respiratory tract infections since Oral sitafloxacin was rapidly absorbed and has a high bioavailability, including widely distributed into various tissues [3].

According to a population pharmacokinetic PK analysis of sitafloxacin in Japanese subjects, changes in covariates could effect on the PK parameters [4]. Thus, physiological changes in critically ill patients may alter the PK of sitafloxacin. The aim of this study was to develop a population PK model for sitafloxacin in Thai critically ill patients with pneumonia. Sitafloxacin was given as a mg single dose on fasting stage. Serial blood samples seven time points were collected in each patient prior to the first dose of sitafloxacin and at 0.

One- and two-compartment model were tested to characterize pharmacokinetics and the covariates were screened for their significant impact on the PK parameters. The final PK model was validated using bootstrap analysis. Results: The median age and weight of the patients were 57 [range ] years and 52 [range Plasma concentrations of sitafloxacin were best described by one-compartment model with first-order absorption.

Clearance CL , volume of distribution V and absorption rate constant Ka were estimated to be 7. Increase in age will lead to a smaller volume of distribution.