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This study included the patients who were diagnosed with influenza between and The primary outcome of this study was critical illness. The secondary analysis was to predict in-hospital mortality. A two-stage-modeling method was developed to predict hospital mortality.

We constructed a multiple logistic regression model to predict the outcome of critical illness in the first stage, then S1 score were calculated. In the second stage, we used the S1 score and other data to construct a backward multiple logistic regression model. The area under the receiver operating curve was used to assess the predictive value of the model.

In the present study, patients met the inclusion criteria. The overall ICU admission and in-hospital mortality was The area under the curve for the stage I and II model was 0.