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Aim: This study aimed to evaluate the association between tamoxifen use and hip fractures in older women with breast cancer in Taiwan. Methods: We carried out a retrospective nationwide case-control study using the database of the Taiwan National Health Insurance Program. Patients were defined as having used tamoxifen if they had an existing prescription for tamoxifen before the index date.

Patients were defined as having never used tamoxifen if they had never been given a prescription for tamoxifen before the index date. Results: After adjustment for confounding variables, compared with patients who did not use tamoxifen, the adjusted odds ratio of hip fracture was 2. Furthermore, adjusted odds ratios were 2. Conclusion: Tamoxifen use is associated with increased risk of hip fractures among older women with breast cancer in Taiwan. Geriatr Gerontol Int ; Keywords: adverse effect; aromatase inhibitors; epidemiology; osteoporosis; selective estrogen receptor modulator.

Abstract Aim: This study aimed to evaluate the association between tamoxifen use and hip fractures in older women with breast cancer in Taiwan. Substances Antineoplastic Agents, Hormonal Tamoxifen.