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The clinical trend and characteristics of peptic ulcer disease PUD have not fully been investigated in the past decade. We analyzed seven hospital databases converted into the Observational Medical Outcomes Partnership-Common Data Model between and Of the patients, Patients with drug-related PUD had significantly more comorbidities and concomitant ulcerogenic drugs. The idiopathic PUD group had a significantly higher number of patients with chronic liver disease.

With the aging population increase, the effects of concomitant ulcerogenic drugs and preventive strategies should be investigated in drug-induced PUD. Further studies are required to clarify the relationship between idiopathic PUD and chronic liver disease. Core Tip: In the multicenter study including peptic ulcer disease PUD patients from 7 databases, the overall number of PUD exhibited no decrease, whereas PUD in old age revealed an increasing trend from to in Korea. According to etiology, decreasing trend of Helicobacter pylori -related PUD after year , and increasing trend of drug-related PUD were observed in the past decade.

Drug-related PUD showed significantly more comorbidities and exposure to concomitant ulcerogenic drugs, and the idiopathic PUD group had a significantly higher proportion in the chronic liver disease.

Peptic ulcer disease PUD remains a critical cause of hospitalization, particularly when complicated by hemorrhage, perforation, or obstruction[ 1 ]. The overall decline of H. Consequently, trends of PUD have demonstrated inconsistent results among regions[ 2 - 7 ].