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Logistic regression was utilized to investigate the relationship between sex and oral anticoagulant, rhythm control strategies and the 1-year chance to maintain sinus rhythm. Cox-regression was utilized to assess the 1-year risk of all-cause, and cardiovascular death, thromboembolic events, acute coronary syndrome, heart failure, and major bleeding. Coronary artery disease was more prevalent in males Females had a higher use of oral anticoagulant On multivariable analyses, females were less often treated with rhythm control strategies Odds Ratio [OR] 0.

Cox-regressions analysis showed no sex-related differences for the risk of death, cardiovascular, and bleeding. The clinical management of Asian AF patients should consider several sex-related differences. Atrial fibrillation AF is one of the most common arrhythmias worldwide and is associated with an increased risk of cardiovascular events and death 1. In patients with AF several differences in terms of clinical presentation, therapeutical management, and long-term outcomes are related to sex 2 , 3.

Females are often more symptomatic, have a higher prevalence of comorbidities and a higher risk of thromboembolic events compared to males 2 , 3 , 4. The mechanisms responsible for these differences are unknown, yet previous studies suggest the involvement of anthropometric, hormonal, structural, and electrophysiological factors 5. However, most studies that investigated sex differences in patients with AF have been conducted in Western populations whereas less information is available about their generalizability to other ethnic groups.