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Also, it is the most widely used clinical marker of diabetic nephropathy. In this early phase of diabetic nephropathy, the glomerular filtration rate is usually well preserved. In patients with several cardiovascular risks, albuminuria is predicting outcome, even below the level to be taken as normal. It seems that the pathophysiologic mechanisms linking albuminuria to cardiovascular and renal risk are generalized loss of vascular endothelial function in organs.

Furthermore, albuminuria can be used as a target for treatment for primary and secondary prevention of renal and cardiovascular disease development. ACE inhibition in subjects with nondiabetic albuminuria may prevent future cardiovascular events.

Measurement of albuminuria can help to determine whether or not the patient with hypertension should be treated, how aggressively they should be treated, and what medications we should treat them with. This is a preview of subscription content, log in via an institution to check access.