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Thank you for visiting nature. You are using a browser version with limited support for CSS. To obtain the best experience, we recommend you use a more up to date browser or turn off compatibility mode in Internet Explorer. In the meantime, to ensure continued support, we are displaying the site without styles and JavaScript. This work aims at studying the spatio-temporal evolution of the age at menopause in central Portugal since the early twentieth century.

One of the concerns was about early or late menopause thus we considered percentile regression to build the respective percentile curves inside the package GAMLSS in R. In order to capture the correlation at the regional level, a spatial random-effect was considered. The obtained clustered spatial effects were analyzed to assess geographical differences among the percentiles of the age at menopause by year of birth. An increasing trend in the median age at menopause and regional differences for all the considered percentiles were found.

From Apart from being a biological threshold for human reproduction, it seems to have a really tight biological-age interval in which it must occur.

Women having their menopause outside that interval have an increased risk for several health problems, namely type 2 diabetes 1 and some types of cancer. Later Age at Menopause AaM has been associated with an increased risk of breast cancer 2 and an early onset of menopause associated with an increased risk of several other diseases such as: cardiovascular 3 , neurological, psychiatric, osteoporosis, and other sequelae 4. On the other hand, longer overall survival and greater life expectancy are associated with later AaM 5 , 6.