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Thank you for visiting nature. You are using a browser version with limited support for CSS. To obtain the best experience, we recommend you use a more up to date browser or turn off compatibility mode in Internet Explorer.
In the meantime, to ensure continued support, we are displaying the site without styles and JavaScript. We found 75 risk loci, of which 42 were new at the time of analysis. Gene prioritization in the new loci identified 31 genes that were suggestive of new genetically associated processes, including the tumor necrosis factor alpha pathway through the linear ubiquitin chain assembly complex.
The improvement in prediction led to a 1. AD is the most common form of dementia. However, much of the underlying heritability remains unexplained. Hence, increasing the sample size of genome-wide association studies GWASs is an obvious solution that has already been used to characterize new genetic risk factors in other common, complex diseases e. A new dataset of 20, clinically diagnosed AD cases and 22, controls has been collated from 15 European countries.
This method has been used successfully in the past 3 but is less specific than a clinical or pathological diagnosis of AD; hence, we will refer to these cases as proxy AD and related dementia proxy-ADD. After validation by conditional analyses Supplementary Note and Supplementary Tables 3 and 4 , this approach enabled us to define 39 signals in 33 loci already known to be associated with the risk of developing ADD 3 , 5 , 6 , 7 , 8 , 9 , 10 and identify 42 loci defined as new at the time of analysis Tables 1 and 2 , Supplementary Table 5 and Supplementary Figs.
