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Objectives Patients with chronic obstructive pulmonary disease COPD are at increased risk of cerebrovascular disease, which might be associated with decreases in cerebral blood flow.

Since studies examining cerebral blood flow in COPD remain scarce and are limited by sample size, we aimed to study cerebral blood flow in participants with and without COPD. Participants participants age Outcome measures Cerebral blood flow by two-dimensional phase-contrast cerebral MRI. In sex-stratified analyses, this difference in cerebral blood flow was statistically significant in women but not in men.

You will be able to get a quick price and instant permission to reuse the content in many different ways. The population-based nature of the Rotterdam Study minimises the risk for selection bias. The large number of participants in this study allowed us to perform multivariable adjustments in regression analyses, reducing the risk of confounding bias.

By using data from the fifth round of the Rotterdam Study, a healthy survivor effect may dilute and underestimate the effect between predictor and outcome. Residual confounding could be due to unmeasured intracranial stenotic lesions or variability in arterial blood gasses, for which we were unable to adjust for.