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Topiramate is already known to cause serious birth defects when used during pregnancy. Topiramate containing medicines are used in the European Union EU for the treatment of epilepsy and prevention of migraine. In some EU countries, the medicine is also used in combination with phentermine for weight reduction. At present, topiramate must not be used to prevent migraine or manage body weight during pregnancy and patients who can become pregnant must use effective birth control when using topiramate.
For patients using topiramate for the treatment of epilepsy, the medicine should not be used during pregnancy unless there is no other suitable treatment available. The CMDh has also agreed to additional measures, in the form of a pregnancy prevention programme, to avoid exposure of children to topiramate in the womb.
These measures will inform any woman or girl who is able to have children of the risks of taking topiramate during pregnancy and the need to avoid becoming pregnant while taking topiramate. Healthcare professionals should ensure that all patients who can become pregnant are fully aware of the risks of taking topiramate during pregnancy.
Alternative treatment options should be considered and the need for topiramate treatment should be reassessed at least annually. The product information for topiramate-containing medicines will be updated to further highlight the risks and the measures to be taken.