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In the meantime, to ensure continued support, we are displaying the site without styles and JavaScript. An Author Correction to this article was published on 30 July Like other App family proteins, Aplp1 is a single-pass transmembrane protein implicated in synaptic adhesion Aplp1 possesses a large N-terminal extracellular domain and a small intracellular C-terminal region Source data are provided as a Source Data file.

The purity of the endolysosome fraction has been validated with mitochondrial, nuclear, and cytosol markers Supplementary Fig. The E1 domain deletion mutant significantly decreases the intensity of co-localization compared to full-length Aplp1 Fig. To test this hypothesis, we investigated the interaction between Aplp1 and Lag3.

To support that Lag3 is expressed in neurons, we determined the co-localization of anti-Lag3 and anti-NeuN in four brain regions of WT mice including the cortex Supplementary Fig. Experiments in a — e were repeated three times independently with similar results.

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