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Object: The authors retrospectively reviewed the results of Gamma Knife surgery GKS used as the sole treatment for brain metastases in patients who met the eligibility criteria for the ongoing JLGK multi-institutional prospective trial. They also discuss the anticipated results of the JLGK study. Methods: Data from consecutive cases were analyzed. At the initial treatment, all visible lesions were irradiated with GKS without upfront whole-brain radiation therapy. Thereafter, gadolinium-enhanced MR imaging was performed every months, and new distant lesions were appropriately retreated with GKS.

Patients were divided into groups according to numbers of tumors: Group A, single lesions cases ; Group B, tumors cases ; and Group C, tumors cases. The differences in overall survival OS were compared between groups.

Results: The median age of the patients was 66 years range years. There were men and women. The primary tumors were in the lung in patients, gastrointestinal tract in , breast in , urinary tract in 66, and other sites in The overall mean survival time was 0. Conclusions: The results of this retrospective analysis revealed an upper CI of 1. Abstract Object: The authors retrospectively reviewed the results of Gamma Knife surgery GKS used as the sole treatment for brain metastases in patients who met the eligibility criteria for the ongoing JLGK multi-institutional prospective trial.