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A Comment to this article was published on 08 August We determined the associations of follow-up blood pressure BP after stroke as a time-dependent covariate with the risk of subsequent ischemic stroke, as well as those of BP levels with the difference in the impact of long-term clopidogrel or aspirin monotherapy versus additional cilostazol medication on secondary stroke prevention. In a sub-analysis of a randomized controlled trial CSPS. The percent changes, differences, and raw values of follow-up BP were examined.

The primary efficacy outcome was the first recurrence of ischemic stroke. In a total of patients Such significant associations were not observed in diastolic BP-derived variables.

Lower long-term SBP levels after ischemic stroke were associated with a lower risk of subsequent ischemic events. The efficacy of dual antiplatelet therapy including cilostazol for secondary stroke prevention was evident over a wide SBP range. Long-term treatment with cilostazol, a phosphodiesterase 3 inhibitor, coupled with aspirin or clopidogrel was shown to halve the risk of recurrent ischemic stroke and have a similar risk of severe or life-threatening bleeding compared to aspirin or clopidogrel alone in patients at high risk for recurrent noncardioembolic ischemic stroke in a randomized, controlled trial, the Cilostazol Stroke Prevention Study for Antiplatelet Combination CSPS.