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Thymic epithelial cells TECs and hematopoietic antigen presenting cells HAPCs in the thymus microenvironment provide essential signals to self-reactive thymocytes that induce either negative selection or generation of regulatory T cells Treg , both of which are required to establish and maintain central tolerance throughout life.

Changes that occur in the composition and function of TEC and HAPC subsets across the lifespan have potential consequences for central tolerance. In keeping with this possibility, there are age-associated changes in the cellular composition and function of T cells and Treg.

This review summarizes changes in T cell and Treg function during the perinatal to adult transition and in the course of normal aging, and relates these changes to age-associated alterations in thymic HAPC and TEC subsets.

Throughout life, the immune system must balance the opposing goals of mounting protective responses against diverse pathogens, while preventing a breakdown in self-tolerance. Neonates encounter a barrage of new pathogens, requiring broad and rapid immune protection, at a time when their immune system is skewed towards mounting tolerogenic responses essential for tissue homeostasis 1.