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Positive and negative effects of cellular senescence during female reproductive aging and pregnancy

Cellular senescence is a phenomenon occurring when cells are no longer able to divide even after treatment with growth stimuli. Because senescent cells are typically associated with aging and age-related diseases, cellular senescence is hypothesized to contribute to the age-related decline in reproductive function.

However, some data suggest that senescent cells may also be important for normal physiological functions during pregnancy. Herein, we review the positive and negative effects of cellular senescence on female reproductive aging and pregnancy. We discuss how senescent cells accelerate female reproductive aging by promoting the decline in the number of ovarian follicles and increasing complications during pregnancy.

We also describe how cellular senescence plays an important role in placental and fetal development as a beneficial process, ensuring proper homeostasis during pregnancy. Cells have a limited capacity to replicate. Once this limit is reached, cells are no longer able to divide, even after treatment with growth stimuli.

This limit is called the Hayflick limit or cellular senescence Hayflick Because lack of regenerative potential is a hallmark of tissue aging, senescent cells are often associated with aging and age-related diseases Herbig et al. Indeed, the number of senescent cells increases with age in multiple tissues Dimri et al.

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