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SARS-CoV-2 has been associated with an increased rate of venous thromboembolism in critically ill patients. Since surgical patients are already at higher risk of venous thromboembolism than general populations, this study aimed to determine if patients with peri-operative or prior SARS-CoV-2 were at further increased risk of venous thromboembolism.

We conducted a planned sub-study and analysis from an international, multicentre, prospective cohort study of elective and emergency patients undergoing surgery during October Patients from all surgical specialties were included. The primary outcome measure was venous thromboembolism pulmonary embolism or deep vein thrombosis within 30 days of surgery. Information on prophylaxis regimens or pre-operative anti-coagulation for baseline comorbidities was not available.

Postoperative venous thromboembolism rate was 0. After adjustment for confounding factors, patients with peri-operative adjusted odds ratio 1. Overall, venous thromboembolism was independently associated with day mortality 5.

Optimal venous thromboembolism prophylaxis and treatment are unknown in this cohort of patients, and these data should be interpreted accordingly.