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Atrial fibrillation AF is a major increasing public health problem worldwide, with clinical and epidemiological differences between men and women. However, contemporary population-level data on incidence and survival are scarce.

To evaluate sex-specific contemporary trends in the incidence, prevalence, and long-term survival of non-valvular AF in a real-world setting. AF patients diagnosed between —, insured by a large, state-mandated health organization in Israel Maccabi Healthcare Services were included. AF was diagnosed based on registered diagnoses.

Annual incidence rate, period prevalence, and 5-year survival for each calendar year during the study period, were calculated. A total of 15, eligible patients 8, males, 7, females were identified. Males were more likely to be younger, have higher rates of underlying diseases ischemic heart disease, heart failure, and chronic obstructive pulmonary disease , but with lower rates of hypertension and chronic kidney diseases as compared to female patients.

During the study period, age-adjusted incidence decreased both in men: The five-year survival rate was significantly higher among men vs. A significant trend toward improved long-term survival was observed in women and not in men. The current study shows significant sex-related disparities in the incidence, prevalence, and survival of AF patients between —; while the adjusted incidence of both has decreased over-time, prevalence and mortality decreased significantly only in women.