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Group A Streptococcus has a varied presentation that ranges from seemingly benign pharyngitis and skin infections impetigo to more severe glomerulonephritis and sepsis, as well as devastating rheumatic heart disease RHD , toxic shock syndrome, and necrotizing fasciitis.

Accurate estimates of the global disease burden are important in planning for disease control, allocating resources, advocating for interventions, prioritizing new strategies and research and providing baseline data to evaluate future interventions. This is particularly relevant in light of the potential to invest in the development of a vaccine to control Group A Streptococcal disease Moreland, et al.

However, overall disease burden estimates are difficult, mainly because of the scarcity of comprehensive disease registries, the reliance on passive surveillance systems, and the underreporting of both acute and chronic cases. At that time, it was estimated that a minimum of A subsequent review published in provided updated data on the RHD burden from Asia, which estimated between 1. These studies also highlighted the dramatic gaps in reliable recent disease burden data from many regions, particularly Asia, Eastern Europe, and Latin America.