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Objectives: To provide a description of the main characteristics of UVAL, determine the most appropriate diagnostic process and describe the current therapeutic approach. Methods: We designed a retrospective, descriptive cohort study using the gynecological-ER database of our institution.

Data extraction : epidemiological characteristics, clinical presentation, laboratory tests, established diagnostics, treatment, and ulcer outcomes. Conclusions: We highly recommend the diagnostic and therapeutic algorithms developed by Sadoghi et al. It manifests itself with one or more highly painful vulvar ulcerations characterized by an acute onset. Their average duration is two weeks 5 , and recurrences are possible but not frequent 6.

Topical corticosteroids are frequently chosen for UVAL treatment. Nevertheless, spontaneous resolution of the ulcers is often described in existing literature 7 — 9.

An association with positive serology for viral and bacterial pathogens such as EBV, CMV, and Mycoplasma Pneumonia has been described in several case series and reports. Two hypotheses have been proposed: one suggests that the cytotoxic effect of the virus causes ulceration and triggers a febrile state in the patient, while the second hypothesis suggests that ulceration is a result of a non-specific inflammatory state in response to systemic viral infection.