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Harmful alcohol drinking habits, even among Roma children and adolescents, are more common than in the majority population. The aim of the study was to evaluate the genetic susceptibility of Roma to hazardous alcohol consumption compared to the Hungarian general population.

A total of samples from the population of segregated Hungarian Roma colonies and samples from the Hungarian general population were genotyped for 25 polymorphisms. Differences in genotype and allele distributions were investigated. Genetic risk scores GRS were generated to estimate the joint effect of individual single-nucleotide polymorphisms SNPs. After unweighted and weighted GRS were calculated the distribution of scores in study populations was compared.

The median weighted genetic risk score was lower among the subjects of Roma population compared to the subjects of general population 0. Differences in alcohol consumption habits between the Hungarian Roma and Hungarian general populations do not appear to be linked to genetic constitution, this behaviour may occur as a result of different cultural values and environmental exposures. Population-based measures to tackle the fundamental drivers of consumption, which take account of cultural acceptability, are needed to reduce harmful alcohol consumption in the Roma population.

The development of alcohol use disorders is a multifactorial process. It includes both genetic and environmental factors. Thus, the heritability of alcohol dependence is relatively high, ranging from 50 to 60 percent, based on twin and adoption studies, and a number of polymorphisms in genes involved in alcohol metabolism and neurotransmission have been linked to alcohol dependence Buscemi and Turchi, However, environmental factors also play an important role, as is apparent from evidence of social patterning of alcohol dependence Batty et al.