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Last updated: April 07, Years published: , , , , , Rheumatic fever is an inflammatory disease that is rare in the United States but common in some other parts of the world. It primarily affects children between the ages of 6 and 16, and develops after an infection with streptococcal bacteria, such as strep throat or scarlet fever. In more than half of all cases, it leads to serious inflammatory disease of the valves of the heart. Joint disease is the second most common consequence of rheumatic fever.

The streptococcal infection that precedes rheumatic fever may or may not be noticeable as a sore throat. After a latent period of two or three weeks, the patient may develop symptoms of rheumatic fever. The most common symptoms are: sore throat; swollen, red tonsils; fever; headache; and joint and muscle aches, especially in the knees.

The most serious problem that can be caused by rheumatic fever is rheumatic heart disease. The membranes lining the heart chambers may be inflamed endocarditis , the muscle walls of the heart may be inflamed myocarditis , the membrane surrounding the heart may be inflamed pericarditis , or any combination of these symptoms may occur.

A heart murmur not previously present, enlargement of the heart cardiomegaly , congestive heart failure, and pericardial friction rubs or leakage of blood from vessels into heart tissue may be signs of rheumatic carditis. Inflammation and subsequent scarring of heart valves occurs in patients with this disorder, and can lead to heart function abnormalities. Such symptoms may disappear after a few weeks or months. If the disorder affects connective tissue or the autoimmune system, painless, firm, round lumps underneath the skin subcutaneous nodules may develop over bones and near joints.