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Dosing: Dosage recommendations are based on the trimethoprim TMP component. For serious infections, gentamicin should be added for the initial 1 to 2 weeks and therapy may be extended for up to 4 to 6 months Ref.
Typical treatment duration is 7 to 10 days, though longer durations may be required in immunocompromised patients Ref. Cystoisosporiasis Cystoisospora infection; formerly isosporiasis : Limited data available:. Melioidosis Burkholderia pseudomallei infection : Limited data available:. Duration should be individualized based on pathogen, patient characteristics, and response; treatment duration for gram-negative bacilli and S.
With repeatedly positive cultures, therapy should be continued for at least 10 to 14 days after first negative cerebrospinal fluid culture Ref.
Osteoarticular infection step-down therapy following parenteral treatment : Very limited data available:. Otitis media, acute alternative agent : Note: Not considered appropriate empiric therapy for acute otitis media due to significant Streptococcus pneumoniae resistance Ref.