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Path analysis suggested that body mass index did not have mediating effect on Apo-HbA1c association. Glycated haemoglobin HbA1c , an integrated measure of circulating blood glucose levels during the previous 2 to 3 months, is considered as a gold standard for long period follow-up of blood glycemic control 1 , 2. Elevated HbA1c level is one of the predominant risk factors for diabetes and its complications 3. Stratton et al.

Therefore, it is urgent to explore the novel modifiable factors of HbA1c for the improvement of diabetes and its complications. Apolipoproteins, a main protein part of lipoproteins, play an important role in the pathological process of type 2 diabetes mellitus 5 , 6. Apolipoprotein A1 ApoA1 is the major lipoprotein associated with high-density lipoprotein cholesterol HDL-C and exert a key part in the transfer of cholesterol from the periphery to the liver in the circulation 7.