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Although many of these disorders are paralleled by either hypocorticism, glucocorticoid GC resistance, or a combination of both, resulting in a decreased GC signalling, the underlying aetiology of these disorders is still poorly understood, at least partly due to a lack of appropriate and clinically relevant animal models. Importantly, not all people are equally affected by chronic stressors. While some individuals subjected to severe adverse life events develop pathologies, others do not. But again, the underlying mechanisms engendering resilience and vulnerability are also far from being understood and, thus, the possibility to clinically benefit from these observations is currently still limited.

A failure of immunoregulation, attributable to reduced exposure to the microbial environment within which the mammalian immune system evolved "Old friends hypothesis" , is thought to be one factor contributing to recent increases in stress-related chronic inflammatory disorders, as well as mood disorders for which chronic low-grade inflammation is a risk factor "cytokine theory of depression" Lowry et al.

Therefore, the main research aims of the Laboratory for Molecular Psychosomatics are to extend the current knowledge on the mechanisms underlying 1i stressor-induced development of somatic and mental pathologies and 1ii individual differences in stress resilience and 2 to use this mechanistic knowledge for the development of novel strategies in terms of stress protection Fig. Effects of early life stress on bone homeostasis and fracture healting.

Reber and M. Mycobacterium vaccae immunization: Inducing resilience to stress during pregnany in the dam and protecting her offspring. Reber Ulm and D. Facilitating stress resilience by "Old friends": Immunization with Mycobacterium vaccae prevents the negative effects of early life stress on chronic stress vulnerability during adulthood.

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