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The aim was to investigate prevalence of dry eye syndrome DES in a population-based sample in Germany. The association between coexisting eye diseases and DES was also of interest. We performed interaction analyses between sex and coexisting eye diseases in relation to the DES prevalence and performed bias analyses to examine the robustness of the results. The DES prevalence was Among DES subjects, There was synergism between female sex and coexisting eye diseases cataract, glaucoma, macular degeneration in terms of DES prevalence.

The extrapolated numbers of patients aged 62—91 years with DES in Germany are 1. The observed synergism may be explained by differences in ocular physiology, subjective perception and response behavior. Women with eye diseases cataract, glaucoma, macula degeneration appear to have a markedly higher susceptibility to suffer from DES than men, so that a diagnostic workup of DES symptoms is particularly justified in women with these eye diseases.

Dry eye syndrome DES is a form of keratoconjunctivitis that causes a variety of symptoms including dryness, irritation, itching, burning and fluctuating vision as it affects the tear film and ocular surface.