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HPV was found in Colorectal cancer CRC is the second most prevalent cancer globally in both genders, ranking the third among diseases overall. It holds the unfortunate distinction of being the second leading cause of mortality attributed to cancer [ 1 ].

CRC was recognized as the sixth form of cancer among Egypt's most prevalent malignancies in , based on the country's national cancer registry. Furthermore, it has been estimated that between and , there would probably be an increase in the CRC cases [ 2 ]. CRC is characterized by complex molecular alterations. Critical key germline and somatic variants causing CRC worldwide were reported previously [ 3 ].

Beyond genetics, the global cancer landscape's intricacies reveal a link to infections. Recent data emphasize infection's role in altering global cancer incidence [ 4 ].