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We explored the effect of a catch-up HPV test among to year-old women without previous record of HPV-based screening. The minimum follow-up time was 13 months for all tested women range: 13 to 25 months. In the intervention group, 6, For the benefit—harm ratio, The study design entails a risk of confounding due to the lack of randomization. This study informs the current scientific debate as to whether women aged 65 and above should be offered a catch-up HPV test if they never had an HPV test.

PLoS Med 20 7 : e This is an open access article distributed under the terms of the Creative Commons Attribution License , which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. Data Availability: Deidentified patient level data may be available for scientific purposes with permissions from Danish Patient Safety Authority: e-mail: stps stps. Funding: The study was partly funded by the Health Foundation grant no.

The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript. According to the contract between Roche and the Department of Public Health Programmes, Randers Regional Hospital, Roche has no influence on the scientific process and no editorial rights pertaining to this manuscript.

The authors retained the right to submit the manuscript. LKP: None related to this topic. AH: I have received reagents for free from Roche Diagnostics for another study. The relatively high incidence and mortality of cervical cancer in women above the current screening age have raised concern in countries with well-established cervical cancer screening programs [ 1 — 4 ].