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Federal government websites often end in. The site is secure. Preview improvements coming to the PMC website in October Learn More or Try it out now. Data were carefully documented in the methods and results sections.

Data are also available from Dryad appendix 1, doi. Further anonymized data can be shared by request from any qualified investigator. We conducted a multicentre, historically prospective study. Data were sourced from the Danish National Patient Registry, the Danish Multiple Sclerosis Registry, departments of neurology, and laboratories providing aquaporin-4 antibody test. Cases were selected based on the Wingerchuk and the IPND criteria and were individually validated by an expert panel.

Defined by the criteria, the incidence of NMO was 0. Our estimates of incidence and prevalence are similar to other Caucasian population—based studies using the IPND criteria.

We found no geographical clustering in Denmark. In AQP4-Ab—seronegative cases, at least 2 of the 6 core clinical features supported by MRI lesion are required, and one of the clinical features has to be 1 of the 3 most common clinical features ON, TM, area postrema syndrome. Previous epidemiologic studies are diverse in the size of the target population, the method of case ascertainment, and the AQP4-Ab measurement table 1.