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Thank you for visiting nature. You are using a browser version with limited support for CSS. To obtain the best experience, we recommend you use a more up to date browser or turn off compatibility mode in Internet Explorer. In the meantime, to ensure continued support, we are displaying the site without styles and JavaScript. Polygenic risk scores PRS have great potential to guide precision colorectal cancer CRC prevention by identifying those at higher risk to undertake targeted screening.
However, current PRS using European ancestry data have sub-optimal performance in non-European ancestry populations, limiting their utility among these populations. Towards addressing this deficiency, we expand PRS development for CRC by incorporating Asian ancestry data 21, cases; 47, controls into European ancestry training datasets 78, cases; , controls.
Colorectal cancer CRC is a leading cause of cancer death, yet it is among the most preventable cancers via screening 1. Together with the detection of CRC at early stages, which dramatically improves prognosis, optimal screening has the potential for a major impact on CRC mortality.
However, current screening programs are primarily age and family-history based and more refinement through risk-based screening recommendations could be instrumental in improving their effectiveness. Genetics plays a key role in the CRC development and, as for most cancers and other common diseases, the risk is polygenic 2.