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Autoimmune diseases affect women disproportionately. In the U. The incidence of rheumatoid arthritis RA is typically two to three times higher in women than men. The onset of RA, in both women and men, is highest among those in their sixties. Certain individuals are genetically susceptible to developing autoimmune diseases. This susceptibility is associated with multiple genes and other risk factors. In many autoimmune diseases three main sets of genes are suspected.

These genes are related to: 4. Although a predisposition to autoimmune disease can run in families, some family members can be affected by different disorders; for example, one person may have diabetes, while another has rheumatoid arthritis.

Several modifiable risk factors have been studied in association with RA, including reproductive hormonal exposures, tobacco use, dietary factors, and microbial exposures. Among all risk factors, the strongest and most consistent evidence is for an association between smoking and RA. A history of smoking is associated with a modest to moderately 1.