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When produced by the Sertoli cells in the seminiferous tubules of the testis , it is called androgen-binding protein ABP. Other steroid hormones such as progesterone , cortisol , and other corticosteroids are bound by transcortin.

SHBG is found in all vertebrates apart from birds. SHBG inhibits the function of these hormones. Thus, the local bioavailability of sex hormones is influenced by the level of SHBG. Because SHBG binds to testosterone T and dihydrotestosterone DHT , these hormones are made less lipophilic and become concentrated within the luminal fluid of the seminiferous tubules.

The higher levels of these hormones enable spermatogenesis in the seminiferous tubules and sperm maturation in the epididymis. SHBG levels are usually about twice as high in women as in men. SHBG is produced mostly by the liver and is released into the bloodstream. Other sites that produce SHBG include the brain, uterus, testes, and placenta. SHBG comes with the 1L, 2, 3, 4, 5, 6, 7, and 8 exons connected together. There are variations in the genetic material for this protein that have different effects.

In humans common polymorphisms include the following:. Rs, also called AspAsn location on Chromosome 17, results in there being an extra N-glycosilation site, and so an extra sugar can be attached. This results in a longer circulation half-life for the protein, and raised levels. A health effect is a lowered risk of endometrial cancer , and another is an increased risk of systemic lupus erythematosus.