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Research Article Oncology Open Access Phone: Find articles by Li, Y. Find articles by Wu, S. Find articles by Zhao, Y. Find articles by Dinh, T. Find articles by Jiang, D. Find articles by Selfridge, J. Find articles by Myers, G. Find articles by Wang, Y. Find articles by Zhao, X. Find articles by Tomchuck, S. Find articles by Dubyak, G. Find articles by Lee, R. Find articles by Estfan, B.
Find articles by Shapiro, M. Find articles by Kamath, S. Find articles by Mohamed, A. Find articles by Huang, S. Find articles by Huang, A. Find articles by Conlon, R. Find articles by Krishnamurthi, S. Find articles by Eads, J. Find articles by Willis, J. Find articles by Khorana, A. Find articles by Bajor, D. Find articles by Wang, Z. Published January 9, - More info. Chemotherapy, which primarily acts on cancer cells, can influence the tumor microenvironment and the recruitment and behavior of stromal cells.
In this issue of the JCI, Li et al. This chemotherapy treatment strongly induced the recruitment of neutrophils that formed neutrophil extracellular traps in cancer, which actively killed cancer cells by inducing apoptosis.
This study substantially advances our understanding of the multifaceted role of neutrophils and NETs in the outcome of anticancer treatment. Neutrophil extracellular traps NETs , a web-like structure of cytosolic and granule proteins assembled on decondensed chromatin, kill pathogens and cause tissue damage in diseases.