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We do this in large measure by studying the health of women and the similarities and differences in health outcomes between and among women and men. As we pursue our work, it is particularly important to use language that captures the different concepts of sex and gender so that our science and our findings can be more precise and better serve everyone.

What do we mean by sex and gender? Perhaps at some point in time they were used as synonyms, but this is no longer true in science. In , a committee convened by the Institute of Medicine IOM , a nonprofit think tank that took on issues of importance to the national health, addressed the question of whether it mattered to study the biology of women as well as men. The IOM, now embedded within the National Academies of Science, Engineering, and Medicine NASEM , concluded there was more than sufficient evidence that, beyond reproductive biology, there were major differences in the biology of women and men that greatly affected their health and influenced treatment and prevention strategies.

Importantly, the committee emphasized that neither the health of women nor men is simply a product of biology but is also influenced by sociocultural and psychological experience. The committee advised that scientists use these definitions in the following ways:.

These working definitions were a good start in recognizing the value of studying sex and gender and their interactions, yet they were always meant to evolve. Now, we are learning more about ourselves and so must adapt our terminology to be inclusive, respectful, and more accurate. For example, while most people are born biologically female or male, rare biological syndromes can result in genital ambiguity.