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Insulin Receptor Substrate-2 in β-Cells Decreases Diabetes in Nonobese Diabetic Mice

Thank you for visiting nature. You are using a browser version with limited support for CSS. To obtain the best experience, we recommend you use a more up to date browser or turn off compatibility mode in Internet Explorer.

In the meantime, to ensure continued support, we are displaying the site without styles and JavaScript. Fasting and fed-state hyperglycemia observed in the HFD-fed mice Fig.

Furthermore, the TUNEL staining protocol detects cells in later stages of cell death with the dead cells being scavenged immediately. To complement the data using pancreas sections Fig. This model allows better assessment of cell death susceptibility under various experimental conditions and in response to defined stimuli.

Such information is difficult to acquire using solely in vivo models, due to lack of knowledge of the kinetics of the cell death process and the need for greater numbers of mice to achieve statistically significant data.

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