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Advanced or recurrent endometrial cancer EC no longer amenable to surgery or radiotherapy is a life-threatening disease with limited therapeutic options left.

This phase 2 trial was performed to assess the efficacy and safety of AEZS in this group of patients. Prior anthracycline therapy was not allowed. Patients received AEZS as a 2-hour infusion on day 1 of a day cycle.

The treatment was continued for a maximum of 6 to 8 cycles. The primary end point was the response rate determined by the Response Evaluation Criteria in Solid Tumors. Forty-three of these patients were eligible. The median time to progression was 7 months, and the median overall survival was 15 months. Endometrial cancer EC is the most common malignancy of the genital tract of women living in industrialized countries.

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