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Members of the genus Brucella are pathogenic bacteria exceedingly well adapted to their hosts. The bacterium is transmitted by direct contact within the same host species or accidentally to secondary hosts, such as humans. Human brucellosis is strongly linked to the management of domesticated animals and ingestion of their products. Since the domestication of ungulates and dogs in the Fertile Crescent and Asia in and ya , respectively, a steady supply of well adapted emergent Brucella pathogens causing zoonotic disease has been provided.

Likewise, anthropogenic modification of wild life may have also impacted host susceptibility and Brucella selection. Domestication and human influence on wild life animals are not neutral phenomena. Management conditions, such as clustering, selection, culling, and vaccination of Brucella preferred hosts have profound influences in the outcome of brucellosis and in the selection of Brucella organisms.

Countries that have controlled brucellosis systematically used reliable smooth live vaccines, consistent immunization protocols, adequate diagnostic tests, broad vaccination coverage and sustained removal of the infected animals. To ignore and misuse tools and strategies already available for the control of brucellosis may promote the emergence of new Brucella variants.

The bacterium preferentially replicates within phagocytic cells of the reticuloendothelial system, and in the pregnant animal, inside placental trophoblasts. In domesticated animals, brucellosis is mainly manifested by abortion and epididymitis. Under natural conditions, Brucella is horizontally or vertically transmitted.