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To determine the extent and magnitude of the kdr -type mutations responsible for this resistance, lice were collected from collection sites in 48 U. Previously published data were used for comparisons of the changes in the frequency of the kdr -type mutations over time.

The frequencies of kdr -type mutations did not differ regardless of the human population size that the lice were collected from, indicating a uniformly high level of resistant alleles. The loss of efficacy of the Nix formulation Prestige Brand, Tarrytown, NY from to was correlated to the increase in kdr -type mutations. These data provide a plausible reason for the decrease in the effectiveness of permethrin in the Nix formulation, which is the parallel increase of kdr -type mutations in lice over time.

Pediculus humanus capitis De Geer , the human head louse, causes one of the most prevalent human parasitic infestations, pediculosis Gratz , Raoult and Roux Although head lice are not known to vector life-threatening human diseases Pittendrigh et al. Recently, three new treatments, Ulesfia Concordia Pharmaceuticals Inc. Nevertheless, the pyrethrins or pyrethroids continue to dominate the louse treatment market as inexpensive and easily obtainable over-the-counter OTC formulations Clark The natural pyrethrins were formulated as a pediculicide in Durand et al.