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Introduction: The distress caused by gender incongruence has been shown to be reduced with gender-affirming care. The current study follows a cohort of patients that requested gender-affirming care at Ghent University Hospital and examines the outcome of the procedures. Methods: The prospective design with 4 assessment times allows the study to assess the evolution of self-reported quality of life QoL and gender incongruence throughout a medical transition process.

Results: The results suggest that gender incongruence improves after surgery. QoL has slightly different trends for the different gender groups: compared to people who were assigned male at birth AMAB , people who were assigned female at birth AFAB report lower QoL after gonadectomy. Meeting other transgender people facilitate QoL after starting hormone therapy. A higher number of friends after genital surgery are predictive of a better QoL. Clinical implications: These results may be useful for clinicians working with transgender patients, as they provide information collected assessing patients soon after surgery and may raise awareness regarding the specific clinical attention that postsurgery patients need.

Conclusions: QoL can be compromised after the invasive surgery, while gender incongruence is alleviated throughout the transition. Our results should be confirmed with other prospective study designs that include a longer follow-up period. J Sex Med ; Published by Elsevier Inc. All rights reserved. Abstract Introduction: The distress caused by gender incongruence has been shown to be reduced with gender-affirming care.