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When low doses of cancer drugs are administered continuously near malignant brain tumours using so-called iontronic technology, cancer cell growth drastically decreases. The results is one step closer to new types of effective treatments for severe cancer forms. Malignant brain tumours often recur despite surgery and post-treatment with chemotherapy and radiation.
The most effective drugs cannot pass through the so-called blood-brain barrier — a tight network surrounding blood vessels in the brain that prevents many substances in the blood from entering it. Consequently, there are very few available options for treating aggressive brain tumours. At that time, experiments were conducted on tumour cells in a petri dish. Now, the same research group has taken the next step towards using this technology in clinical cancer treatment. By allowing glioblastoma cells to grow using undeveloped bird embryos, new treatment methods can be tested on living tumours.
The researchers showed that the growth of cancer cells decreased when low doses of strong drugs gemcitabine were continuously administered using an iontronic pump directly adjacent to the brain tumour. Now we use a model with a living tumour, and we can see that the pump administers the drug very effectively. The concept behind a future treatment for glioblastoma involves surgically implanting an iontronic device directly into the brain, close to the tumour.
This approach allows for the use of low doses of potent drugs while bypassing the blood-brain barrier. Precise dosing, both in terms of location and timing, is crucial for effective treatment. Beyond brain tumours, researchers hope that iontronics can be applied to many types of difficult-to-treat cancer forms. The researchers compared the continuous drug delivery of the pump with once-daily dosing, which more closely resembles how chemotherapy is administered to patients today.
