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Malaria Journal volume 18 , Article number: 93 Cite this article. Metrics details. Great progress has been made in recent years to reduce the high level of suffering caused by malaria worldwide.
Notably, the use of insecticide-treated mosquito nets for malaria prevention and the use of artemisinin-based combination therapy ACT for malaria treatment have made a significant impact. Nevertheless, the development of resistance to the past and present anti-malarial drugs highlights the need for continued research to stay one step ahead.
New drugs are needed, particularly those with new mechanisms of action. Here the range of anti-malarial medicines developed over the years are reviewed, beginning with the discovery of quinine in the early s, through to modern day ACT and the recently-approved tafenoquine. A number of new potential anti-malarial drugs currently in development are outlined, along with a description of the hit to lead campaign from which it originated.
Finally, promising novel mechanisms of action for these and future anti-malarial medicines are outlined. In , the World Health Organization WHO estimated that there were million cases of malaria worldwide, an increase of 2 million from the previous year, and as a result there were thousand deaths, or per day, mostly young children [ 1 ]. There are five species of the Plasmodium parasite, with Plasmodium falciparum being the most prevalent in Africa and Plasmodium vivax being the most prevalent in countries outside Africa.
