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Federal government websites often end in. The site is secure. Preview improvements coming to the PMC website in October Learn More or Try it out now. To date, ZIKV infection has been documented in 66 countries.
ZIKV is recognized as a neurotropic virus and numerous diseases manifested in multiple neurological disorders have been described, mainly in countries that have been exposed to ZIKV after the outbreak in the Federated States of Micronesia. The most dramatic consequence of ZIKV infection documented is the abrupt increase in fetal microcephaly cases in Brazil. Here, we present an update of the published research progress in the past few months.
Although Zika virus ZIKV was described 70 years ago, it only became a public health problem at the end of when an outbreak in Brazil was associated with a significant increase of microcephaly cases in fetus and newborns. Since then, scientists all over the world are rushing to study the pathogenesis of ZIKV infection and understand the differences of infection between the first described strain African MR, which only caused some mild symptoms, and the one identified in Asia at the Yap Island of the Federated States of Micronesia in and later in French Polynesia in , which resembles the one in Brazil.
New scientific information about ZIKV is available almost daily. Although a few great reviews have been recently published, important information has been described since then. Here we present an update review with the latest available information. Detailed reviews may be found elsewhere [ Lazear and Diamond, ; Musso and Gubler, ; Petersen et al. The virus was subsequently detected in humans in other areas of Africa, and South and Southeast Asia in the following years [ Smithburn, , ; Macnamara, ; Smithburn et al.
