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Federal government websites often end in. The site is secure. Preview improvements coming to the PMC website in October Learn More or Try it out now. The South African clawed frogs Xenopus laevis and X. Because genetically engineered laboratory Xenopus are now being produced, the establishment of normal reference ranges for serum biochemical and hematologic parameters is essential for phenotyping and as a diagnostic aide.

We determined normal reference ranges for hematologic values from 3 populations of X. For serum biochemistry, we determined normal reference ranges for frogs from source A and wild-caught frogs divided by sex and season. Significant differences across populations were found in WBC and RBC counts, hemoglobin concentration, hematocrit, mean corpuscular hemoglobin concentration, and mean corpuscular volume. We hypothesize that these differences can be attributed to differences in water quality, habitat, ambient temperature, diet, sex, recent transport or shipment, and genetic background.

However, testing that hypothesis is beyond the scope of the current study. In addition, clinical chemistry and hematologic reference range values Xenopus laevis are quite distinct from those for other species and are most consistent with the only values published for another fully aquatic amphibian, the Eastern hellbender Cryptobranchus alleganiensis.

The South African clawed frog, Xenopus laevis , has a long history in biomedical research. The complete X. In addition, these values will assist in disease surveillance and the diagnosis of clinical illnesses and conditions. Previously published hematograms have been reported on a very limited number of laboratory Xenopus : 10 normal adult frogs sex and source not described 9 and 7 normal adult, female laboratory Xenopus ; 8 however, the number of animals studied were insufficient to establish reference ranges.